何军伟,男,1985年1月,博士,博士后,校聘教授,硕士生导师,江西省主要学科学术和技术带头人。
主要从事中药与民族药的药效物质、作用机制及质量标准研究,以第一/通讯作者在Bioorganic Chemistry、Biomedicine & Pharmacotherapy、Frontiers in Pharmacology、International Immunopharmacology、Journal of Ethnopharmacology等国际高水平杂志发表SCI论文35篇。相关研究获得国家自然科学基金、江西省自然科学基金等课题资助,省部级科技二等奖2项(均排第1),授权专利2项。兼任国家自然科学基金/江西省自然科学基金同行评议专家、赣江新区生物医药专家,International Journal of Biological Macromolecules、Biomedicine & Pharmacotherapy、International Immunopharmacology、Journal of Ethnopharmacology等20余个sci杂志审稿专家。
先后指导研究生和本科生获得国家级创新创业基金项目2项、省级创新创业基金项目4项、校级创新创业基金项目6项。
教育研究经历:
2021/05‒至今:江西中医药大学,中药资源与民族药研究中心,校聘教授
2020/12‒至今:江西中医药大学,中药资源与民族药研究中心,副教授
2015/10‒2018/06:江西中医药大学,博士后(在职,合作导师:钟国跃教授)
2014/07‒2020/11:江西中医药大学,中药资源与民族药研究中心,讲师
2011/09‒2014/06:暨南大学,药学院,生物医药工程/博士,导师:姚新生院士
2008/09‒2011/06:暨南大学,药学院,药物化学/硕士,导师:姚新生院士
2004/09‒2008/06:湖南中医药大学,药学院,中药学/学士
主要学术奖励:
1.何军伟,等. 民族药“同物异用”的科学内涵研究−以夏至草和玉簪为例。中国民族医药学会,科学技术二等奖,2020年。
2.何军伟,等. 蒙药玉簪花治疗Ⅲ型前列腺炎的药效物质基础及总黄酮提取工艺研究。中国民族医药学会,科学技术二等奖,2019年。
获人才项目:
1.省级人才计划(2.2020年):江西省主要学科学术和技术带头人培养计划(青年)。
近三年发表的第一/通讯作者SCI论文(按照时间倒序,*为通讯作者):
1. Yang L, Cao L, Li CL, Li XB, Wang JS, Chen HP, He JW*. Hostaflavone A from Hosta plantaginea (Lam.) Asch. blocked NF-κB/iNOS/COX-2/MAPKs/Akt signaling pathways in LPS-induced RAW 264.7 macrophages. Journal of Ethnopharmacology, 2022, 282:114605.(IF = 4.360,中科院医学2区)
2. Yang L, He JW*. Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NF-kB signaling pathway. BMC Complementary Medicine and Therapies, 2022, 22:55.(IF = 3.659,中科院医学2区)
3. Yang L, Fang YW, He JW*. Plantanone C attenuates LPS-stimulated inflammation by inhibiting NF-κB/iNOS/COX-2/MAPKs/Akt pathways in RAW 264.7 macrophages. Biomedicine & Pharmacotherapy, 2021, 143:112104.(IF = 6.529,中科院医学2区)
4. He JW, Yang L*. Diuretic effect of Lagopsis supina fraction in saline-loaded rats is mediated through inhibition of aquaporin and renin-angiotensin-aldosterone systems and up-regulation of atriopeptin. Biomedicine & Pharmacotherapy, 2021, 139:111554.(IF = 6.529,中科院医学2区)
5. Yang L, Liu RH, Ouyang S, Zhou M, Duan YL, Li LM, Guan T, Zhang T, He JW*. Compounds DRG and DAG, two phenol glycosides inhibit TNF-α-stimulated inflammatory response through blocking NF-kB/AKT/JNK signaling pathways in MH7A cells. Inflammation, 2021, 44(5):1762-1770.(IF = 4.092,中科院医学2区)
6. Yang L, Liu RH, Fang YW, He JW*. Anti-inflammatory effect of phenylpropanoids from Dendropanax dentiger in TNF-α-induced MH7A cells via inhibition of NF-κB, Akt and JNK signaling pathways. International Immunopharmacology, 2021, 94:107463.(IF = 4.932,中科院医学2区)
7. Yang L, He ZW, He JW*. The chemical profiling of aqueous soluble fraction from Lagopsis supina and its diuretic effects via suppression of AQP and RAAS pathways in saline-loaded rats. Journal of Ethnopharmacology, 2021, 272:113951.(IF = 4.360,中科院医学2区)
8. Yang L, Liu RH, Fan AG, Zhong GY, He JW*. Dendropanax dentiger (Harms) Merr. root and its major constituents exert therapeutic effect on adjuvant-induced arthritis in rats. Journal of Ethnopharmacology, 2021, 267:113631.(IF = 4.360,中科院医学2区)
9. Yang L, He JW*. Traditional uses, phytochemistry, pharmacology and toxicological aspects of the genus Hosta (Liliaceae): A comprehensive review. Journal of Ethnopharmacology, 2021, 265:113323.(IF = 4.360,中科院医学2区)
10. Yang L#, Zhu YY#, He ZW, Zhang TF, Xiao ZX, Xu RL, He JW*. Plantanone D, a new rare methyl-flavonoid from the flowers of Hosta plantaginea with anti-inflammatory and antioxidant activities. Natural Product Research, 2021, 35(22):4331-4337.(IF = 2.861,中科院化学3区)
11. Yang L, Liu SZ, Liu RG, He JW*. Bioassay-guided isolation of cyclooxygenase-2 inhibitory and antioxidant phenylpropanoid derivatives from the roots of Dendropanax dentiger. Bioorganic Chemistry, 2020, 104:104211.(IF = 5.275,中科院化学2区)
12. Yang L, He JW*. Lagopsis supina extract and its fractions exert prophylactic effects against blood stasis in rats via anti-coagulation, anti-platelet activation and anti-fibrinolysis and chemical characterization by UHPLC-qTOF-MS/MS. Biomedicine & Pharmacotherapy, 2020, 132:110899.(IF = 6.529,中科院医学2区)
13. Yang L, Liu RH, Fan AG, Zhao JJ, Zhang Y, He JW*. Chemical composition of Pterospermum heterophyllum root and its anti-arthritis effect on adjuvant-induced arthritis in rats via modulation of inflammatory responses. Frontiers in Pharmacology, 2020, 11:584849.(IF = 5.810,中科院医学2区)
14. Yang L, Fang YW, Liu RH*, He JW*. Phytochemical analysis, anti-inflammatory and antioxidant activities of Dendropanax dentiger roots. BioMed Research International, 2020, 2020:5084057.(IF = 3.411,中科院生物学3区)
15. He JW, Wu LF, Yang L*, Zhao BY, Li CL. Extraction of phenolics and flavonoids from four Hosta species using reflux and ultrasound-assisted methods with antioxidant and α-glucosidase inhibitory activities. BioMed Research International, 2020, 2020:6124153.(IF = 3.411,中科院生物学3区)
16. Zhang SW, Cheng F, Yang L*, Zeng JX, Han FY, Yu XL, Zhu YY, Zhong GY, He JW*. Chemical constituents from Glehnia littoralis and their chemotaxonomic significance. Natural Product Research, 2020, 34(19):2822-2827.(IF = 2.861,中科院化学3区)
17. Yang L#, Lin YM#, He ZW, Zhang TF, Xie XT, Wu YF, He JW*. Hostaflavanol A, a new anti-inflammatory and antioxidant activities flavanol from the flowers of Hosta plantaginea. Medicinal Chemistry Research, 2020, 29(3):426-430.(IF = 1.965,中科院医学4区)
18. He JW*, Zeng LB, Wei RR, Zhong GY, Zhu YY, Xu TT, Yang L*. Lagopsis supina exerts its diuretic effect via inhibition of aquaporin-1, 2 and 3 expression in a rat model of traumatic blood stasis. Journal of Ethnopharmacology, 2019, 231:446-452.(IF = 4.360,中科院医学2区)
19. Yang L, He JW*. Hosta plantaginea (Lam.) Aschers (Yuzan): An overview on its botany, traditional use, phytochemistry, quality control and pharmacology. RSC Advances, 2019, 9(60):35050-35058.(IF = 3.361,中科院化学3区)
20. Yang L, Liu RH*, He JW*. Rapid analysis of the chemical compositions in Semiliquidambar cathayensis roots by ultra high-performance liquid chromatography and quadrupole time-of-flight tandem mass spectrometry. Molecules, 2019, 24(22):4098.(IF = 4.411,中科院化学3区)
21. Liu ZY#, Yang L#, Li lx, Wei RR, Luo XQ, Xu TT, Huang Y, Mu ZJ, He JW*. Diuretic and anti-diuretic activities of ethanol extract and fractions of Lagopsis supina in normal rats. BioMed Research International, 2019, 2019:6927374.(IF = 3.411,中科院生物学3区)
22. He JW, Huang XY, Wang YQ, Liang J, Liu RH, Zhong GY*, Yang L*. A new flavonol glycoside from the flowers of Hosta plantaginea with cyclooxygenases-1/2 inhibitory and antioxidant activities. Natural Product Research, 2019, 33(11):1599-1604.(IF = 2.861,中科院化学3区)
科研项目(部分):
1.国家自然科学基金,青年基金项目(项目编号:81503357),2016/01-2018/12、18万、已结题、主持。
2.江西省自然科学基金,人才基金项目(项目编号:20204BCJL23047),2020/01-2022/12、30万元、在研、主持。
3.江西省自然科学基金,重点研发项目(项目编号:20171BBH80026),2017/01-2019/12、20万元、已结题、主持。
4.江西省自然科学基金,青年基金项目(项目编号:20192BAB215059),2019/01-2020/12、6万元、结题、主持。
5.江西省自然科学基金,青年基金项目(项目编号:20161BAB215209),2016/01-2017/12、5万元、已结题、主持。
6.中国博士后科学基金,面上一等项目(项目编号:2016M600514),2016/10-2018/06、8万元、已结题、主持。
7.江西省博士后科学基金,科研择优资助项目(项目编号:2016KY50),2016/07-2018/06、3万元、已结题、主持。
8.国家药典委员会,药品标准制修订研究课题(项目编号:2018Z092),2018/07-2019/12、12万元、结题、共同主持。
9.横向课题,国药集团广东环球制药有限公司,2020/09-2020/11、23万元、结题、主持。
10.横向课题,西藏藏医药大学,2018/09-2020/12、33万元、结题、主持。
授权发明专利:
1.杨丽, 何军伟, 刘荣华. 树参中的香豆素类化合物及其在制备治疗炎症性疾病药物中的用途, ZL202010854436.2.
2.钟国跃, 朱继孝, 何军伟, 张寿文. 玉簪花及其提取物在制备治疗慢性前列腺炎的药物或保健食品中的用途, ZL201710954397.1.
参编著作:
1.何军伟, 编委,8/30,民族药成方制剂处方药材‒品种、基原与标准,人民卫生出版社,2020年4月,书号ISBN 978-7-117-25161-7。
联系方式:
地址:南昌市新建区梅岭大道1688号,江西中医药大学,中药资源与民族药研究中心B618室
电话:13767098949
邮箱:hjwjn2008@163.com
(2022年3月22日更新)